The Influence of VEGF-A Signaling on Beta-Cell Regeneration, by Tracee Popielarczyk

“Our journal club discussions have revolved around the current management, treatment, and cures for diabetes and potential regenerative medicine strategies; however, much is still unknown about the underlying processes and signaling mechanisms involved in pancreatic development and its role in this disease. It is known that β-cells exhibit a low regenerative capacity, making the molecular and cellular factors in β-cell regeneration of interest for both type 1 and type 2 diabetes. A 2014 study published in Cell Metabolism by Brissova, M. et al. investigated the influence of vascular endothelial growth factor-A (VEGF-A) signaling on β-cell regeneration. Three main questions were addressed in this article and are summarized below.

What is VEGF-A and what is its importance in pancreatic cell populations?”READ MORE on Tracee’s blog

 

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